Highlighted Publications

Small-molecule inhibition of viral fusion glycoproteins.
Liu HY, Yang PL. Annu Rev Virol. 2021 Sep 29;8(1):459-489. doi: 10.1146/annurev-virology-022221-063725. Epub 2021 Jul 1. Review. PubMed PMID: 34197186; PubMed Central PMCID: PMC8543812.

Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.
Tallorin L, Villareal VA, Hsia CY, Rodgers MA, Burri DJ, Pfeil MP, Llopis PM, Lindenbach BD, Yang PL. J Biol Chem. 2020 Aug 28;295(35):12426-12436. doi: 10.1074/jbc.RA120.013455. Epub 2020 Jul 8. PubMed PMID: 32641492; PubMed Central PMCID: PMC7458815.

Targeted protein degradation as an antiviral approach. Chakravarty A, Yang PL. Antiviral Res. 2023 Feb;210:105480. doi: 10.1016/j.antiviral.2022.105480. Epub 2022 Dec 22. PubMed PMID: 36567024; PubMed Central PMCID: PMC10178900.

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.  Nat Commun. 2019 Aug 1;10(1):3468. doi: 10.1038/s41467-019-11429-w. PMID: 31371704; PMCID: PMC6672008.