My research group focuses on understanding the mechanisms responsible for viral replication and development of new strategies to combat viral pathogens. We combine chemical biology, medicinal chemistry, and molecular virology approaches to tackle challenges in both basic and translational research.
Over the past decade, our efforts have centered on two significant problems: first, addressing the challenges that limit our current arsenal of antivirals and second, understanding the specificity and function of host lipids in RNA virus replication. We are keenly interested in discovery of new antiviral targets and strategies and leveraging these discoveries to develop first-in-class small molecule antivirals. We also have a strong interest in developing or adapting tools from chemistry, chemical engineering, and biophysics to probe new areas of virology.
We are most excited to be moving to the Department of Microbiology and Immunology during the 2020-2021 school year! We’re recruiting new lab members at all levels – the most important qualification is that you have a keen interest in the kinds of questions we pursue.
Although in need of updating, our Harvard website Yanglab.med.harvard.edu may be useful in getting a sense of our group.Email Us » Publications »